GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | trans | rs1056667 | 1 | rs2224380 | chr6:26553943 | ZNF322B | chr9:99957633-99961910:- | 0.57 | 11.17 | 6.6E-26 | Educational attainment |
| THCA | trans | rs1056667 | 1 | rs2255070 | chr6:26501777 | ZNF322B | chr9:99957633-99961910:- | 0.54 | 10.2 | 3.09E-22 | Educational attainment |
| THCA | trans | rs877636 | 1 | rs2292239 | chr12:56482180 | RPS26P11 | chrX:71264259-71264809:+ | 0.47 | 8.44 | 3.93E-16 | Cognitive function |
| THCA | trans | rs6600671 | 1 | rs2319969 | chr1:121207335 | NBPF14 | chr1:148003643-148346791:- | 0.4 | 8.82 | 2.11E-17 | Hip geometry |
| THCA | trans | rs1056667 | 1 | rs2393670 | chr6:26535541 | ZNF322B | chr9:99957633-99961910:- | 0.54 | 10.29 | 1.42E-22 | Educational attainment |
| THCA | trans | rs7824557 | 1 | rs2736371 | chr8:11105529 | SGK223 | chr8:8175259-8239257:- | 0.33 | 6.26 | 8.67E-10 | Retinal vascular caliber |
| THCA | trans | rs853679 | 1 | rs2799077 | chr6:28234597 | BTN3A2 | chr6:26365398-26378546:+ | -0.51 | -9.96 | 2.38E-21 | Depression |
| THCA | trans | rs853679 | 1 | rs2799079 | chr6:28235176 | BTN3A2 | chr6:26365398-26378546:+ | -0.49 | -9.62 | 3.95E-20 | Depression |
| THCA | trans | rs1056667 | 1 | rs28558133 | chr6:26531433 | ZNF322B | chr9:99957633-99961910:- | 0.54 | 10.29 | 1.42E-22 | Educational attainment |
| THCA | trans | rs1056667 | 1 | rs3736781 | chr6:26505362 | ZNF322B | chr9:99957633-99961910:- | 0.55 | 10.32 | 1.08E-22 | Educational attainment |
| THCA | trans | rs1056667 | 1 | rs3736782 | chr6:26505403 | ZNF322B | chr9:99957633-99961910:- | 0.55 | 10.32 | 1.08E-22 | Educational attainment |
| THCA | trans | rs41266839 | 1 | rs41266839 | chr6:26409890 | ZFP57 | chr6:29640171-29648887:- | 0.91 | 7.48 | 3.61E-13 | Schizophrenia |
| THCA | trans | rs995030 | 1 | rs4284478 | chr12:88907563 | ATP6V1B1 | chr2:71162998-71192560:+ | -0.42 | -5.97 | 4.56E-9 | Testicular germ cell tumor |
| THCA | trans | rs4533720 | 1 | rs4533720 | chr4:164959804 | FOXJ2 | chr12:8185359-8208117:+ | -0.24 | -5.88 | 7.82E-9 | Urinary uromodulin levels |
| THCA | trans | rs766432 | 1 | rs4671393 | chr2:60720951 | HBG1 | chr11:5269502-5271087:- | -0.45 | -6.42 | 3.33E-10 | Beta thalassemia/hemoglobin E disease;F-cell distribution;Fetal hemoglobin levels;Hemoglobin A2 levels in sickle cell anemia;Sickle cell anemia (haemolysis) |